Three-month raL Appearance and overt behavior were recorded daily; body weight was determined weekly. Blood was collected from the caudal artery prior to dosing and during Weeks 5 and 9 of the study. At termination, blood for hematology parameters was obtained from the caudal artery and for clinical chemistry parameters blood was obtained from the abdominal aorta. Prior to dosing and during Weeks 5 and 9 of the study, the blood samples were analyzed for hematocrit, erythrocyte count, leukocyte count, hemoglobin, reticulocyte count, platelet count, differential leukocyte count, glucose, urea nitrogen, and alanine aminotransferase. Terminal blood samples were analyzed for the above plus prothrombin time, erythrocyte sedimentation rate, activated partial thromboplastin time, aspartate aminotransferase, CTeatinine, total protein, alkaline phosphatase, cholesterol, potassium, sodium, chloride, and total bihrubin. Twenty-four-hour urine samples were collected on ice-dry ice mixture from all rats prior to dosing and during Weeks 5, 9, and 13. These samples were analyzed for volume, pH, specific gravity, creatinine, osmolality, urea nitrogen, protein, bilirubin, glucose, occult blood, ketone, and microscopic sediment. At necropsy, organ weight was recorded for heart, adrenals, spleen, liver, brain, lungs, kidneys, ovaries, and testes with epididymides. Samples of these tissues and aorta, pituitary, thyroid parathyroid, esophagus, stomach, duodenum, pancreas, lleum, jejunum, cecum, thymus, mesenteric lymph node, tracheobronchial lymph node, bone marrow, colon, salivary gland, spinal cord, sciatic nerve, trachea, urinary bladder, mammary gland, uterus, prostate, femur, thigh muscle, skin, eyes, and optic nerve were taken and processed for microscopic examination. Three-month dog. Appearance, overt behavior, and food consumption were recorded daily; body weight was recorded weekly. Blood pressure, heart rate, and electrocardiograms were recorded prior to dosing and during Weeks 4, 8, and 13 of the study. Ophthalmoscopic examination was performed at the same intervals. Blood samples for drug level assays were collected during Weeks 4, 8, and 13 of the study. Blood samples collected prior to dosing and during Weeks 4, 8, and 13 of the study were analyzed for total erythrocyte count, hematocrit, hemoglobin, sedimentation rate, total leukocyte count, differential leukocyte count, platelets, prothrombin time, activated partial thromboplastin time, glucose, urea nitrogen, alanine aminotransferase, aspartate aminotransferase, total protein, creatinine, total bilirubin, sodium, potassium, chloride, A G ratio, cholesterol, and uric acid. Twenty-four-hour urine samples collected at the same intervals were analyzed for pH, specific gravity, volume, color, character, glucose, ketone, protein, and microscopic sediment. At necropsy, organ weights were recorded for the kidneys, liver, lungs, ovaries, pituitary, spleen, testes, and thyroids. Samples of these tissues and skin, adrenals, abdominal aorta, inferior vena cava, femur, brain, cecum, cervical lymph nodes, colon, costochondral junction, duodenum, esophagus, eyes, gallbladder, heart, ileum, jejunum, mammary gland, mesenteric fat, mesenteric lymph node, pancreas, prostate, salivary glands, sciatic nerve, thigh muscle, sternum, stomach cardiac, fundic, pyloric ; , spinal cord, thymus, trachea, urinary bladder, uterus, and all gross lesions were taken and processed for microscopic examination. Chronic Studies One-year rat Appearance, overt behavior, body weight, and food consumption were recorded weekly. Ophthalmic examinations were conducted prior to dosing and at termination of the study. Blood samples collected during Weeks 7, 12, 26, and 52 were analyzed for erythrocyte count, hematocrit, hemoglobin, leukocyte count, differential leukocyte count, urea nitrogen, aspartate aminotransferase, alanine aminotransferase, -y-glutamyl transferase.

FA-A and FA-C, account for approximately 75% of FA patients. Scientists presented preliminary results on mutation screening for FA-A. Unlike FA-C, the mutations for FA-A are numerous and often difficult to detect. FA Gene Products: Apoptosis The increasingly important subject of apoptosis the process of cell death ; was the subject of five presentations. Grover Bagby of Oregon Health Sciences University described how FA-C hematopoietic cells are sensitive to gamma interferon, and why this discovery is important in understanding premature cell death. Transgenic and Knockout Animal Models Manuel Buchwald, Hospital for Sick Children and Markus Grompe, Oregon Health Sciences University discussed recent findings from FA-C mouse models and other researchers explored implications of animal model studies. Carcinogenesis and Leukemogenesis in FA This session examined factors leading to or signalling the progression to leukemia in disorders such as FA. The poorly understood role of clonal abnormalities as predictors of leukemia was examined extensively. Experimental Therapies The final session explored developments in marrow and stem cell transplantation; further reports on the first FA-C gene therapy trial; preparations by one laboratory for FA-A gene therapy; and speculation on the possibility that spontaneous mosaicism in FA might be an example of "natural" gene therapy. x. Or more pulmonary arteries and one or more pulmonary veins. Common anatomic forms include single sacs ranging from 1 to 10 diameter, macroscopic tangles, and microscopic telangiectases. The main complications of PAVMs are believed to relate to right-to-left shunting of blood through the PAVM and include stroke and brain abscess, which together occur in up to one half of patients if untreated.1 Other potentially serious complications include refractory hypoxemia, hemoptysis, and hemothorax. Fortunately, nearly all of these complications can be prevented by embolization of the feeding arteries transcatheter embolotherapy [TCET] ; . PAVMs are associated with underlying hereditary hemorrhagic telangiectasia HHT ; in up to 90% of cases. Conversely, at least 30% of patients with HHT will also have PAVMs. In order to prevent the complications noted above, various screening strategies for PAVMs have been proposed in patients with known HHT or their undiagnosed relatives.1 4 The main screening tests are reviewed in the following paragraphs. Contrast transthoracic echocardiography TTE ; is performed by IV injection of echocardiographic conEditorials Deleted: Maclean D, Ryan Margau. Managing side effects: living with ART. CATIE Fact Sheet, March 23, 2000 and sulfasalazine.

JAMA. 1999; 281: 1701-1706 jama Author Affiliations: The Center for Reproductive Medicine and Infertility and the Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY Drs Xu, Shi, Veeck, and Rosenwaks and the Department of Reproductive Genetics, Wayne State University, Detroit Medical Center, Detroit, Mich Dr Hughes ; . Corresponding Author and Reprints: Zev Rosenwaks, MD, The Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 E 70th St, Room HT326a, New York, NY 10021 e-mail: zrosenw mail.med.cornell ; . JAMA, May 12, 1999--Vol 281, No. 18 1701 and symlin.

OSCaR is working on procedures to provide timely feedback to hospitals after data files have been submitted. Future plans consisted of creating a web-based reporting system for non-registry hospitals and new ideas for promoting the registry profession. Some might compare discussing registry business to daily household chores. Whether the chores are completed in the early morning hours or late at night, they are not always enjoyable, but at the same time are still necessary. Overall, the spring workshop proved to be a success. Comments and reviews received after the workshop were very complimentary. For the most part, the audience considered themselves fortunate to be able to spend the day, plus a few extraunscheduled minutes, in the presence of some highly skilled and entertaining presenters.

TABLE 1. Geometric and Hemodynamic Data Weeks after onset of LV weight Dog identification hypertrophy g ; 2 114 No. 6 No. 7 4 168 No. 10 4 132 No. 11 4 133 No. 12 142 Mean 3.6 4 128 No. 13 sham and synvisc.

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