The Board of Pharmacy had one regulation hearing since the last Newsletter. During the March 21-22, 2005 Board Meeting, Regulation 16.19.20.65 NMAC through 16.19.20.69 NMAC concerning controlled substances was opened. Multiple items were added to Schedules I, II, III, IV, and V. These items were added to mimic the federal controlled substance regulations. The changes will be reflected on the State of New Mexico Web site at nmcpr ate.nm nmac.

As shown in Figure 2, two hypotensive phases were observed. The first hypotensive phase occurred very rapidly after LPS intravenous injection, with a nadir obtained at 1 hour and the arterial pressure decreasing markedly to about 45% of the initial mean pressure levels. No difference was observed between SHR and WKY. This period was followed by a partial recovery until 3 hours after LPS. At that time, a secondary hypotensive phase was observed in WKY, while SHR tended to recover. The mean arterial pressures expressed as a percentage of the initial values ; were found to be significantly higher in SHR than in WKY at 4 hours and 6 hours after LPS P 0.05.

Effect of Starvation on Tumor Acid RNase Activity. Table. The "2004 International Congress on Advances in Nuclear Power Plants ICAPP 2004 ; " will be held in conjunction with the 2004 Annual Meeting. ICAPP 2004 has a full schedule of technical presentations and a few special plenary sessions. Additional information on the ICAPP 2004 Topical Meeting can be found starting on page 26 of the program.

Figure 4. Top, Localization of ET-1 protein by immunohistochemical analysis. At 7 days after inoculation, endothelial cells arrows ; and infiltrating mononuclear cells arrowheads ; are positive for ET-1. Magnification 400. Bottom, Negative control. Primary antibody was absorbed with recombinant human ET-1. Slightly slower killing by erythromycin, clarithromycin, and roxithromycin, especially at earlier time periods. -Lactams were bactericidal against 8 to 10 strains at two times the MIC after 24 h, with slower killing at earlier time periods. Time-kill studies for the five M. catarrhalis strains Table 3 ; showed that all compounds except cefprozil and ceftriaxone were bactericidal at or above the MIC after 24 h, with other -lactams showing more rapid killing at earlier time periods. PAEs are presented in Table 4. As can be seen, ABT-773 and azithromycin gave the longest PAEs of the ketolide-macrolide-azalide group tested 4.4 to 8.0 h ; , followed by clarithromycin, erythromycin, and roxithromycin. -Lactam PAEs were all similar and shorter than those of the ketolide-macrolide-azalide group for all strains tested. DISCUSSION ABT-773 is a new ketolide Ma et al., Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., 1999; Cao et al., Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., 1999 ; which, in preliminary studies, has been reported to be more potent in vitro than the macrolides against H. influenzae, M. catarrhalis, Legionella spp., Neisseria gonorrhoeae, and Listeria monocytogenes. ABT-773 was also more potent against macrolide-susceptible strains of S. pneumoniae, Streptococcus pyogenes, S. aureus, Staphylococcus epidermidis, enterococci, Helicobacter pylori, and Mycobacterium avium complex and also against Corynebacterium spp., Mycoplasma pneumoniae, Chlamydia trachomatis, Borrelia burgdorferi, and Toxoplasma gondii. ABT-773 had potent activity against macrolide-resistant streptococci and enterococci irrespective of their macrolide resistance mechanisms but had little detectable activity against constitutively macrolide-resistant staphylococci and macrolideresistant H. pylori and M. avium complex 2; Shortridge et al., Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., 1999; M. M. Neuhauser, J. L. Prause, R. Jung, N. Boyea, J. M. Hackleman, L. H. Danziger, and S. L. Pendland, Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., abstr 2139, 1999; F. Goldstein, M. D. Kitzis, M. Miegi, and J. F. Acar, Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., abstr. 2142, 1999; A. L. Barry, P. C. Fuchs, and S. D. Brown, Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother., abstr. 2144 and ceftriaxone.

A-B ; + B-C ; + C-D ; + D-E ; 4 Range of Close 1.00 - 0.90 ; + 0.90 - 0.80 ; + 0.80 - 0.90 ; + 0.90 - 1.00 ; 0.10 + 0.10 + -0.10 + -0.10 ; 4 0.00 It is blatantly obvious that our stock experiences an average range of ##TEXT##.10 per day yet as we have selected to ignore the position of the close relative to the previous day our calculations told us that the range was actually zero when we know this to be incorrect. By always subtracting the lower value from the higher value we can determine the true movement of the closing price. A-B ; + B-C ; + D-C ; + E-D ; 4 Range of Close 1.00 - 0.90 ; + 0.90 - 0.80 ; + 0.90 - 0.80 ; + 1.00 - 0.90 ; 0.10 + 0.10 + 0.10 + 0.10 ; 4 0.10 The next element with the minimum close technique is determining the maximum upside. We use the total trading range for each of the most recent five days and then average. Unlike the calculation process used for determining the average movement for the closing price we do not reference any previous days activities. We treat each day separately and as its own entity: High - Low ; + High - Low ; + High - Low ; + High - Low ; + High Low 5 Average Range Once we have determined the average range for our stock we then add the range of price action to the average movement of the closing price. If we intend to project our minimum close technique above a line of resistance then we would apply the process as follows: Resistance + Range of Close Minimum Closing Price Maximum Entry price Minimum Closing Price + Average Daily Range The time has come to apply our minimum closing price technique to price action. Mayne Group is currently testing a line of resistance at .98. How far would price action have to move above the line of resistance before we would consider that a breakout is potentially genuine. Our calculations tell us that the closing price for MAY moves almost ##TEXT##.05 per day on average. The closing would need to move beyond the value of .03 before we would consider that the break is most likely genuine and the impact of the line of resistance is starting to lose its effect. If the closing price fails to reach the minimum target of .03, then the upside movement of the closing price above the line of resistance has been less than average therefore the line of resistance still has some influence over the traders thought process. Lets say that price action has closed at .02 and then declined tomorrow by the average movement of ##TEXT##.05 per day. Price action will have dropped below our line of resistance failing to become support. The range in the closing price was average, yet resistance did not hold to become. Do not take cefprozil if you have ever had an allergic reaction to another cephalosporin or to a penicillin without first talking to your doctor and cerezyme.

A 59-year-old previously healthy male presented as an outpatient with complaints of fatigue, recent 20 pounds weight loss, loss of appetite, and abdominal fullness. Physical examination revealed an abdominal mass in the left upper quadrant. CT scan of the abdomen showed a 19 cm mass with a necrotic center and an irregular soft tissue periphery. The mass was in close approximation to the splenic flexure of the colon, immediately anterior to the pancreas, and displaced the stomach medially. A left hemicolectomy, and splenectomy along with excision of the tail of the pancreas were performed. Gross examination revealed a 25 cm grey, fleshy mass with a necrotic center involving the wall of the left colon apparently arising from the sigmoid mesocolon Figure 1A ; . An ulcer was present in the center of the large bowel segment, likely from pressure effect Figure 1A ; . A homogenous pale yellow, fatty mass was present at the periphery corresponding to the well differentiated component, composed of numerous lipoblasts and fibrous septa Figure 1B ; . At the interface between the fatty and solid areas, the histology showed an abrupt transition from a well-differentiated component to a dedifferentiated component resembling a high-grade malignant fibrous histiocytoma MFH ; Figure 1C ; . The dedifferentiated component was composed of pleomorphic, spindle cells with elongated, hyperchromatic nuclei, admixed with tumor giant cells, and abundant necrosis. The mitotic index was two per high power field and atypical mitoses were easily identified. The dedifferentiated c o m nva d e d Figure 1D ; . Immunolabeling for S-100 was positive in the well-differentiated component as would be expected of a liposarcoma ; . CD117 C-KIT ; and CD34 were negative in the dedifferentiated component, thus ruling out a gastrointestinal stromal tumor GIST ; . Based on the histology and immunoprofile, a diagnosis of dedifferentiated liposarcoma was rendered. Two and a half months postoperatively, a CT scan showed a recurrent mass for which the patient underwent resection of the posterior gastric wall and distal pancreatectomy. The pathologic examination revealed a mass 9.5 cm 5.0 cm 5.0 cm ; , which was morphologically identical to the patient's previous tumor. Following adjuvant radiation therapy the patient was doing relatively well two years after the diagnosis without evidence of recurrent tumor.

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